Endocrine Abstracts

Introduction: Serotonin producing neuroendocrine tumors are usually well differentiated, small lesions localised in the small intestine. Visualisation of the primary tumor might be difficult due to its small size.Case report: A 52 years old man presented with diarrhoea and flushes. Ultrasound examination and computed tomography of the abdomen revealed numerous lesions in the liver. Gastroscopy, colonoscopy and magnetic resonance imaging did not reveal th...

Introduction: Peptide receptor radionuclide therapy is indicated in case of patients with disseminated neuroendocrine tumors and is usually considered as palliative treatment.Case reports: 55 years old man diagnosed with tumor of the pancreatic head. On laparotomy performed in June 2012 tumor was stated unresectable. Histopathological examination revealed the mixed adeno-neuroendocrine cancer (MANEC). Patient was qualified to chemotherapy with gemcitabin...

Introduction: GH therapy in children with normal GH peak in stimulation tests (GHST) is still a matter of discussion. Recently, GH deficiency (GHD) has been defined as secondary IGF1 deficiency (IGFD), however GHST still remain the main procedure in diagnosing GHD.The aim of present study was to compare GH therapy effectiveness in the patients with normal results of GHST (normGH) and with isolated partial GHD (pGHD), with respect to IGF-I secretion befor...

Background and aims: A growing number of studies show the impact of vitamin D deficiency on chronic diseases, such as obesity, type 2 diabetes, cardiovascular disorders etc. Recently the lower limit of vitamin D sufficiency, appeared to be safe and sufficient for skeletal health in the healthy general population, was documented as 20 ng/ml (50 nmol/l). The aim of current work is to evaluate whether the 25-OH vitamin D status is associated with the glucose control in type ...

Neurons expressing the agouti-related protein (AgRP) and the pro-opiomelanocortin (POMC) are part of the central system responsible for regulating energy balance and food intake. The hypothalamus is sensitive to changes in the inflammatory state. Either high-grade inflammation (e.g., caused by sepsis) or low-grade inflammation (caused by obesity) disturbs the hypothalamic function via inflammatory cytokines. Understanding how these cytokines interact and regulate the circuits ...

Objectives: The objective was to evaluate effects of hyperthyroidism and hypothyroidism on bone metabolism in premenopausal women with special emphasis to osteoprotegerin (OPG) and vitamin D3 (vD).Materials and methods: A total of 119 women aged 18–52 years were studied (38 with recently diagnosed hyperthyroidism; 40 with newly diagnosed hypothyroidism; 41 healthy women as controls). Patients were followed up for a period of 1 year. BMD, ...

Introduction.: The diagnosis of GH deficiency (GHD) is based on decreased GH peak in stimulating tests (GHST). Recently, GHD has been re-defined as secondary IGF1 deficiency (IGFD). However, IGF1 may increase during GH therapy in the patients with normal GH peak in GHST, suggesting a diagnosis of non-primary IGFD (npIGFD).The aim of the study was to compare GH therapy effectiveness in children with GHD and with npIGFD (responding to GH administration des...

Introduction: In majority of patients with childhood-onset GH deficiency (GHD), normalisation of GH secretion at the attainment of final height (FH) is observed. However, different criteria for GHD diagnosis may be considered.The aim of the study was to compare the auxological and hormonal data of the patients with persistent and transient GHD, diagnosed according to different criteria.Patients and methods: The analysis comprised 1...

Indications to GH therapy in children with short stature are still a matter of discussion.We compared first-year response to GH therapy in 80 children (62 boys, 18 girls), age 12.7±2.4 years (mean±S.D.) with different disorders of GH secretion. In all the patients nocturnal GH secretion assessed during 3 h after falling asleep was decreased (<10 ng/ml). In 40 children GH deficiency (GHD) was diagnosed on the ground of decreas...

Normal thyroid hormone secretion (or appropriate L-thyroxin substitution) is necessary for the optimal effect GH administration on growing rate. The decrease of free thyroxin (FT4) levels at GH therapy onset was reported in several studies.The aim of our study was to assess the incidence of hypothyroidism (HT) during the initial phase of GH administration in previously euthyroid children with GH deficiency (GHD) and to compare t...